Nicotinamide Adenine Dinucleotide (NAD) is a very serious topic. However, stress is not good for your NAD+ levels and low NAD+ makes you moody, so let’s keep this light hearted as possible and as non-stressing as we can.
NAD is a co-enzyme found in all living cells and it is responsible for controlling boringly critical stuff you never wanted to know about like the cell’s energy production system as well as cellular RNA and DNA repairs. Basically, unlike Fight Club, what happens in the cell affects everything. Basically, it affects us even if we don’t want to know about it.
If levels of NAD+ drop too low, normal energy production gets disrupted and cellular repairs cannot be effected efficiently with catastrophic consequences. In addition, NAD+ is required for a host of inconvenient things including; smooth vascular muscle autonomous repair, that would be an annoyingly critical thing like repairing your heart muscle, and keeping your immune system functioning optimally.
Oh and before we move on, most of the modern ailments have NAD+/SIRT1 disturbances as a root. Bugger! And there we were trying to keep this light hearted.
Fortunately, it is not all doom and gloom. All we need to do is make sure that our NAD+ and SIRT levels are optimal and while that won’t be a cure for everything, it certainly gives us a fighting chance or at the very least, a set of metabolic brass knuckles…
So why has NAD+ become a problem?
Well as we get older NAD+ levels decline, oh wait, doesn’t that suggest that declining NAD+ ages us?
Sadly this seems to be the case and a host of new, and costly, NAD+ boosting supplements are hitting the market. Come on, you didn’t think the fountain of youth, or even the trickle of youth, would be free, or even cost effective, did you? Some big pharmaceutical company has to make their billions.
In addition to naturally declining levels of NAD+ Reactive Oxygen Species or ROS Stress is a major contributor to depletion of NAD+. Yes we are using horribly complicated words again and now comes the stress part, sugar consumption or rather continual hyperglyceamic events, caused by sugar and refined carbs, is also a major complicating factor. You know all that comfort food like chocolates, chips and that ice-cold Coke, the ones that you are wanting reach for right now… Yes, those sugar and refined carb laden foods… Maybe you should just settle for a cold glass of water instead…
And you thought Noakes and those like him were nuts? Maybe not…
Lets meet CD38…
CD 38 (Cluster of Differentiation 38), also known as Cyclic ADP Ribose Hydrolase is a glycoprotein found on the surface of many immune cells.
Ok, we give up, big complicated word and terminology warning.
Basically CD38 is a Glycoprotein which gets over expressed in response to continual hyper insulinemic responses to hyperglyceamic events and inflammation or to put it simply, what happens every time you eat too much sugar or refined carbohydrates. This is really bad because CD38 over-expression, that is too much of it, suppresses NAD+ levels which in turn has a knock-on effect on your glucose control which means you just over-express CD38 even more.
Ok so back to the fountain of youth stuff… Deep breath, blood pressure dropping and back to a mild panic…
While big pharma doesn’t want you getting longevity cheaply, fortunately all they are peddling is an advanced version of good old Vitamin B3, which is dirt cheap.
There are 3 forms of Vitamin B3:
- Nicotinic Acid or NA for short. This is also know as Niacin. Big Pharma isn’t interested in this because its way to cheap and easily available.
- Nicotinamide or NaM for short, is the Amide form of Nicotinic Acid and it’s also known as Niacinamide. Like Na this is also quite cheap so again of not much interest to Big Pharma.
- Nicotinamide Riboside or NR for short, is a pyridine-nucleoside form of vitamin B3 and is a precursor to NAD+. This is really expensive and is loved by Big Pharma.
Actually there is a 4th, Nicotinamide Mono Nucleotide or NMN but it is really a NAD+ precursor not a B3 and besides you would need to sell a kidney to afford it.
While NR is the new high priced kid on the block, there is a lot to suggest that NA or NaM may be almost if not as effective at boosting NAD+ levels and at a fraction of the price. Go figure! Wonder why we don’t hear more about this from Big Pharma…
Ok so you can now afford the fountain of youth, Yay, but hang on a second…
Boosting NAD+ boosts mitochondrial function and that’s been pretty poor up till now thanks in no small part to your diet. How do you think you are going to feed and support that mitochondrial growth and replication as a result of the improved levels of NAD+?
So what if you are on a low carb healthy fat diet? Surely you have nothing to worry about? Well not entirely….
There are a number of studies that point to high fat causing issues because of NAD+ suppression or referencing how NAD+ boosting overcomes problems caused by high fat diets. Both of these points to the fact that High Fat diets suppress NAD+ the question however is what exactly is the definition of High Fat? What is clear is that while you may lose weight on a High Fat diet, if you are scoffing fat bombs, shakes etc and not packing in nutrient density, especially B vitamins, including B3, you are heading for a serious problem down the line.
If you want to read some great information about nutrient density and what to feed your mitochondria, Marty Kendall’s Optimising Nutrition is the place to start.
Now you know why we created MitoFuel. While we don’t promise it will cure or treat anything, it is really good at feeding and supporting hungry mitochondria by combining well researched components in a unique formulation.
Want to know what’s in it? Yeh of course you do, Welcome to MitoFuel